Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation

@article{Brandt2007Dia1AI,
  title={Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation},
  author={Dominique Tobias Brandt and Sabrina Marion and Gareth O Griffiths and Takashi Watanabe and Kozo Kaibuchi and Robert Grosse},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={178},
  pages={193 - 200}
}
The Diaphanous-related formin Dia1 nucleates actin polymerization, thereby regulating cell shape and motility. Mechanisms that control the cellular location of Dia1 to spatially define actin polymerization are largely unknown. In this study, we identify the cytoskeletal scaffold protein IQGAP1 as a Dia1-binding protein that is necessary for its subcellular location. IQGAP1 interacts with Dia1 through a region within the Diaphanous inhibitory domain after the RhoA-mediated release of Dia1… CONTINUE READING

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