Di ff erential e ff ects of high fat diet and diet-induced obesity on skeletal acquisition in female C 57 BL / 6 J vs . FVB / NJ Mice ☆

@inproceedings{Devlina2018DiFE,
  title={Di ff erential e ff ects of high fat diet and diet-induced obesity on skeletal acquisition in female C 57 BL / 6 J vs . FVB / NJ Mice ☆},
  author={M. J. Devlina and A. Robbinsa and M. N. Cosmana and C. A. Moursia and A. M. Cloutierc and L. Louisc and M. Van Vlietc and C. Conlonc and M. L. Bouxseinb},
  year={2018}
}
  • M. J. Devlina, A. Robbinsa, +6 authors M. L. Bouxseinb
  • Published 2018
The effects of obesity on bone metabolism are complex, and may be mediated by consumption of a high fat diet and/or by obesity-induced metabolic dysregulation. To test the hypothesis that both high fat (HF) diet and dietinduced metabolic disease independently decrease skeletal acquisition, we compared effects of HF diet on bone mass and microarchitecture in two mouse strains: diet-induced obesity (DIO)-susceptible C57BL/6J (B6) and DIO-resistant FVB/NJ (FVB). At 3 wks of age we weaned 120… CONTINUE READING

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