Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats.

  title={Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats.},
  author={Barbara J. Davis and Robert R. Maronpot and Jerrold J. Heindel},
  journal={Toxicology and applied pharmacology},
  volume={128 2},
Di-(2-ethylhexyl) phthalate (DEHP) is a known reproductive toxicant and a carcinogen in rodent animal models. DEHP may also be a reproductive toxicant in women. Its action in female animal models is undetermined, although its potential to target the ovary has recently been shown. We have identified the ovarian toxicity and target cells of DEHP in the female rat. Adult, regularly cycling Sprague-Dawley rats were dosed daily with 2 g/kg DEHP in corn oil by gavage for 1 to 12 days. Ovarian… CONTINUE READING
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