Di (2-ethylhexyl) phthalate exposure during pregnancy disturbs temporal sex determination regulation in mice offspring.

@article{Wang2015DiP,
  title={Di (2-ethylhexyl) phthalate exposure during pregnancy disturbs temporal sex determination regulation in mice offspring.},
  author={Yongan Wang and Wei Liu and Qiang Yang and Mingxi Yu and Zhou Zhang},
  journal={Toxicology},
  year={2015},
  volume={336},
  pages={
          10-6
        }
}
Animal researches and clinical studies have supported the relevance between phthalates exposure and testicular dysgenesis syndrome (TDS). These disorders may comprise common origin in fetal life, especially during sex determination and differentiation, where the mechanism remains unclear. The present study evaluated the disturbances in gene regulatory networks of sex determination in fetal mouse by in utero Di (2-ethylhexyl) phthalate (DEHP) exposure. Temporal expression of key sex… CONTINUE READING
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