Dextromethorphan upregulates osteoblast and osteoclast activity but does not attenuate ovariectomy-induced osteoporosis.

@article{Wu2017DextromethorphanUO,
  title={Dextromethorphan upregulates osteoblast and osteoclast activity but does not attenuate ovariectomy-induced osteoporosis.},
  author={Jia-lin Wu and W Tsai and Jian-Horng Chen and C S Wong},
  journal={Life sciences},
  year={2017},
  volume={173},
  pages={145-149}
}
AIMS Study on the in vivo regulatory role of glutamate in osteoblast (OB) and osteoclast (OC) differentiation is less advanced. The present study investigated the effect of dextromethorphan (DXM), an N-methyl-d-aspartate receptors (NMDARs) antagonist, on osteoporosis development. MAIN METHODS In order to examine the role of glutamate in bone metabolism… CONTINUE READING