Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance

@article{Elliott1995DextromethorphanSE,
  title={Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance},
  author={Kathryn J. Elliott and Marina Brodsky and Alexandra Hynansky and Kathleen M. Foley and Charles E Inturrisi},
  journal={Neurology},
  year={1995},
  volume={45},
  pages={S66 - S68}
}
The oral antitussive dextromethorphan is a clinically available N-methyl-D-aspartate receptor antagonist. Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models. These data suggest that dextromethorphan should be evaluated in a controlled clinical trial for analgesic efficacy in zoster-associated… 
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  • Biology, Psychology
    European journal of pharmacology
  • 1999
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Understanding of these morphine-like agents and their receptors has undergone an evolution in thinking over the past 35 years, which now reveals a complexity of the morphine- like agents andtheir receptors that had not been previously appreciated.
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Evidence is emerging that medication-induced enhanced pain is not unique to opioids, but may be generalized to other analgesic classes acting through G-protein coupled receptor systems, which would lead to improved therapeutic management of long-term painful conditions, including recurrent headache.
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