Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance
@article{Elliott1995DextromethorphanSE, title={Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance}, author={Kathryn J. Elliott and Marina Brodsky and Alexandra Hynansky and Kathleen M. Foley and Charles E Inturrisi}, journal={Neurology}, year={1995}, volume={45}, pages={S66 - S68} }
The oral antitussive dextromethorphan is a clinically available N-methyl-D-aspartate receptor antagonist. Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models. These data suggest that dextromethorphan should be evaluated in a controlled clinical trial for analgesic efficacy in zoster-associated…
21 Citations
Antinociceptive and nociceptive actions of opioids.
- Biology, PsychologyJournal of neurobiology
- 2004
The neuroplastic changes elicited by opioid exposure reflect adaptive changes to promote increased pain transmission and consequent diminished antinociception (i.e., tolerance).
Cold Pain Threshold and Role of NMDA Receptor Antagonists
- Medicine
- 2018
Cold pain threshold was higher in men and individuals over than 30-year-old and decreased significantly after administration of clonidine and dextromethorphan conjointly and Acta Med Iran 2018;56(11):720-725.
N‐Methyl‐d‐aspartate receptor modulators block hyperalgesia induced by acute low‐dose morphine
- BiologyClinical and experimental pharmacology & physiology
- 2011
The tail‐flick test was used to assess the effects of morphine alone and in combination with the NMDA receptor modulators on the development of morphine‐induced hyperalgesia in mice.
Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys.
- BiologyThe Journal of pharmacology and experimental therapeutics
- 2002
The antinociceptive effects of DXM administered alone or in combination with morphine or the delta-opioid receptor (DOR) agonist SNC80 were potentiated by DXM and these combinations did not significantly alter RR.
Search for the “ideal analgesic” in pain treatment by engineering the mu‐opioid receptor
- BiologyIUBMB life
- 2010
This article decides to explore the possibility of using virus to deliver the mutant mu‐opioid receptor at the various sites of the nociceptive pathway and induce the antinocICEptive responses with the systemic administration of opioid antagonists.
Modification of naloxone-induced withdrawal signs by dextromethorphan in morphine-dependent mice.
- Biology, PsychologyEuropean journal of pharmacology
- 1999
Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance.
- Biology, PsychologyLife sciences
- 2003
Mu Opioids and Their Receptors: Evolution of a Concept
- BiologyPharmacological Reviews
- 2013
Understanding of these morphine-like agents and their receptors has undergone an evolution in thinking over the past 35 years, which now reveals a complexity of the morphine- like agents andtheir receptors that had not been previously appreciated.
Opioids in the Treatment of Headache: Perspective from the Bench
- Medicine, Biology
- 2006
Evidence is emerging that medication-induced enhanced pain is not unique to opioids, but may be generalized to other analgesic classes acting through G-protein coupled receptor systems, which would lead to improved therapeutic management of long-term painful conditions, including recurrent headache.
References
SHOWING 1-10 OF 34 REFERENCES
Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity
- Biology, MedicineBrain Research
- 1987
Dextromethorphan inhibits NMDA-induced convulsions.
- Biology, ChemistryEuropean journal of pharmacology
- 1988
Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat
- BiologyBrain Research
- 1991
Serotonin-containing neurons: their possible role in pain and analgesia
- Biology, MedicinePain
- 1978
The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
- Biology, PsychologyPain
- 1978
Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids.
- Biology, ChemistryEuropean journal of pharmacology
- 1985
Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801.
- Biology, PsychologyScience
- 1991
The present studies suggest that NMDA receptors may be important in the development of opiate tolerance and dependence.
Dextromethorphan and levorphanol on dorsal horn nociceptive neurones in the rat
- Biology, MedicineNeuropharmacology
- 1991
Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.
- BiologyThe Journal of pharmacology and experimental therapeutics
- 1993
The demonstration that LY274614 can prevent and reverse the development of morphine tolerance without reducing the analgesic response suggests that the adaptive system involved in the development and maintenance of tolerance requires a functional N-methyl-D-aspartate receptor.