Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance

@article{Elliott1995DextromethorphanSE,
  title={Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance},
  author={K. Elliott and M. Brodsky and A. Hynansky and K. Foley and C. Inturrisi},
  journal={Neurology},
  year={1995},
  volume={45},
  pages={S66 - S68}
}
  • K. Elliott, M. Brodsky, +2 authors C. Inturrisi
  • Published 1995
  • Medicine
  • Neurology
  • The oral antitussive dextromethorphan is a clinically available N-methyl-D-aspartate receptor antagonist. Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models. These data suggest that dextromethorphan should be evaluated in a controlled clinical trial for analgesic efficacy in zoster-associated… CONTINUE READING
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