Dextromethorphan for the treatment of neuropathic pain: a double-blind randomised controlled crossover trial with integral n-of-1 design.

@article{McQuay1994DextromethorphanFT,
  title={Dextromethorphan for the treatment of neuropathic pain: a double-blind randomised controlled crossover trial with integral n-of-1 design.},
  author={H. J. McQuay and Dawn Carroll and Alejandro Alex R Jadad and Chris J. Glynn and Timothy Jack and R Andrew Moore and P J Wiffeh},
  journal={Pain},
  year={1994},
  volume={59 1},
  pages={127-33}
}
The aim was to compare the analgesic effectiveness and adverse effect incidence of oral dextromethorphan (DM) with placebo in patients with neuropathic pain. The first 10-day treatment period was a multiple-dose double-blind randomised controlled cross-over comparison of 13.5 mg of DM 3 times a day (t.d.s.) with placebo t.d.s.: 5 treatment pairs, each pair 1 day DM and 1 day placebo. The second 10-day treatment period used 27 mg of DM t.d.s. vs. placebo, with the same design. The study… CONTINUE READING