Dextromethorphan binding sites in the guinea pig brain

@article{Musacchio2004DextromethorphanBS,
  title={Dextromethorphan binding sites in the guinea pig brain},
  author={Jos{\'e} M. Musacchio and Martine Klein},
  journal={Cellular and Molecular Neurobiology},
  year={2004},
  volume={8},
  pages={149-156}
}
Summary1.Dextromethorphan (DM), a dextrorotatory nonopioid antitussive, binds to specific high-affinity sites in the central nervous system. These sites are distinct from the opioid and other known neurotransmitter receptor sites. Antitussives such as carbetapentane and caramiphen also bind to DM sites with a nanomolar affinity.2.The anticonvulsant drugs phenytoin and ropizine produce an allosteric enhancement of the binding of [3H]DM to guinea pig brain. DM, carbetapentane, and caramiphen also… 
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