Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.

@article{Ducharme1996DextromethorphanAA,
  title={Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.},
  author={James Ducharme and Sopiah Abdullah and Irving W Wainer},
  journal={Journal of chromatography. B, Biomedical applications},
  year={1996},
  volume={678 1},
  pages={113-28}
}
Dextromethorphan (DM) is O-demethylated into dextrorphan (DEX) in humans by the cytochrome P450 designated as CYP2D6 and N-demethylated into 3-methoxymorphinan (3MM) via CYP3As. Clinically, DM has been successfully used as an index of CYP2D6 and this paper describes analytical and clinical data that will help evaluate the use of DM hydrobromide as a probe of CYP3A activity. DM and its three demethylated metabolites were measured in a 4-h spot urine sample using a HPLC method employing solid… CONTINUE READING

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