Dextromethorphan and neuromodulation: old drug coughs up new activities.

@article{Tortella1989DextromethorphanAN,
  title={Dextromethorphan and neuromodulation: old drug coughs up new activities.},
  author={Frank C. Tortella and Mariano Pellicano and Norman George Bowery},
  journal={Trends in pharmacological sciences},
  year={1989},
  volume={10 12},
  pages={
          501-7
        }
}
Dextromethorphan is one of the most widely used non-opioid cough suppressants, representing the active ingredient in several over-the-counter antitussive formulations. It does not possess the CNS pharmacology of other opiates in humans (i.e. analgesia, respiratory depression, abuse liability or psychotomimetic properties), but since the discovery in 1981 of high affinity recognition sites in brain for dextromethorphan a unique neuropharmacological profile has emerged for this relatively… CONTINUE READING
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