Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline.

@article{Baumann1992DextromethorphanAM,
  title={Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline.},
  author={Pierre Baumann and J. W. Meyer and Marlyse Amey and Dr. K. B{\"a}ttig and Ch Bryois and Mich{\`e}le Jonzier-Perey and Liliane Koeb and Carole T Monney and Brigitte Woggon},
  journal={Therapeutic drug monitoring},
  year={1992},
  volume={14 1},
  pages={1-8}
}
The metabolism of most tricyclic antidepressants and some phenothiazine neuroleptics is under the genetic control of hepatic cytochrome P-450IID6, which also regulates the metabolism of dextromethorphan. This study investigated the effect of treatment with amitriptyline or thioridazine on testing for genetically regulated efficiency of the metabolism of dextromethorphan and mephenytoin. One group of 33 patients was treated with 150 mg amitriptyline a day (the AMI group); 25 other patients… CONTINUE READING

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