Corpus ID: 12852184

Dextromethorphan and codeine: comparison of plasma kinetics and antitussive effects.

@article{Aylward1984DextromethorphanAC,
  title={Dextromethorphan and codeine: comparison of plasma kinetics and antitussive effects.},
  author={M. Aylward and J. Maddock and D. E. Davies and D. Protheroe and T. Leideman},
  journal={European journal of respiratory diseases},
  year={1984},
  volume={65 4},
  pages={
          283-91
        }
}
Plasma kinetics of dextromethorphan (as dextrorphan ) and codeine were investigated after acute oral doses in 8 patients with pathological cough; after which the patients participated in an acute dose-response study of the antitussive effects of each drug administered as syrups. Maximum plasma codeine concentrations averaged 384 ng.ml-1 (s.d. +/- 78.3) occurring between 0.75 and 2h after ingestion of 60 mg codeine phosphate; in comparison mean peak plasma dextrorphan levels were 386 ng.ml-1 (s… Expand
72 Citations
The antitussive effect of dextromethorphan in relation to CYP2D6 activity.
  • 54
  • PDF
Antitussive agents as N-methylaspartate antagonists: further studies.
  • 45
Pharmacokinetics of pholcodine in healthy volunteers: single and chronic dosing studies.
  • 21
Bioavailability Evaluation of a Controlled‐Release Dextromethorphan Liquid
  • 17
Biowaiver monographs for immediate-release solid oral dosage forms: codeine phosphate.
  • 18
  • Highly Influenced
  • PDF
The Polymorphic Metabolism of Dextromethorphan
  • 43
...
1
2
3
4
5
...