Dextromethorphan and Codeine: Objective Assessment of Antitussive Activity in Patients with Chronic Cough

@article{Matthys1983DextromethorphanAC,
  title={Dextromethorphan and Codeine: Objective Assessment of Antitussive Activity in Patients with Chronic Cough},
  author={Heinrich Matthys and B Bleicher and U Bleicher},
  journal={Journal of International Medical Research},
  year={1983},
  volume={11},
  pages={100 - 92}
}
Dextromethorphan, the most widely used cough suppressant in the U.S.A., was compared with codeine, the traditional European antitussive, in a double-blind, crossover trial using both an objective and subjective assessment of efficacy in sixteen patients with chronic, stable cough. Both preparations, at a dose of 20 mg, were similarly effective in reducing cough frequency. Dextromethorphan lowered cough intensity to a greater degree than codeine (p < 0·0008) and was considered the better… 

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