Dextromethorphan Plus Ultra Low‐Dose Quinidine Reduces Pseudobulbar Affect

@article{Pioro2010DextromethorphanPU,
  title={Dextromethorphan Plus Ultra Low‐Dose Quinidine Reduces Pseudobulbar Affect},
  author={Erik P. Pioro and Benjamin Rix Brooks and Jeffrey L. Cummings and R. Schiffer and Ronald A. Thisted and Daniel R Wynn and Adriana Hepner and Randall Kaye},
  journal={Annals of Neurology},
  year={2010},
  volume={68}
}
To evaluate dextromethorphan combined with ultra low‐dose quinidine (DMq) for treating pseudobulbar affect (PBA) in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). 

Efficacy of Dextromethorphan plus Quinidine Demonstrated for Pseudobulbar Affect

Pseudobulbar affect (PBA), a severe outburst of emotional expression incongruous to a patient's emotional state, can occur in patients with amyotrophic

Dextromethorphan/quinidine for pseudobulbar affect associated with subarachnoid hemorrhage

A 43-year-old woman who developed PBA following an acute subarachnoid hemorrhage with a basilar artery aneurysm is described, who was treated with dextromethorphan/quinidine and showed a reduction in her PBA symptoms.

Pharmacotherapeutic management of pseudobulbar affect.

  • Jack J. Chen
  • Medicine
    The American journal of managed care
  • 2017
This activity will update pharmacists and other healthcare professionals on current treatments for pseudobulbar affect (PBA). Points of discussion will focus on the off-label therapies traditionally

Dextromethorphan/Quinidine: A Review of Its Use in Adults with Pseudobulbar Affect

Although longer-term efficacy and tolerability data for dextromethorphan/quinidine 20/10 or 30/10 mg twice daily would be beneficial, current evidence indicates that it is a useful option in the treatment of adults with PBA.

Dextromethorphan Hydrobromide and Quinidine Sulfate

  • Medicine
  • 2013
The place in therapy of DHQ is not totally elucidated but it may be appropriate to consider it a second line agent except in cases where contraindications to SSRI or TCA exist for specific patients.

Dextromethorphan/quinidine for the treatment of pseudobulbar affect.

  • E. PatatanianJ. Casselman
  • Medicine
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists
  • 2014
Based on the data available, DM/Q may be a viable, short-term treatment alternative for PBA, and long-term safety and efficacy data are lacking.

Review of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA®) for Pseudobulbar Affect

  • E. Pioro
  • Medicine, Psychology
    Neurology and Therapy
  • 2014
Dextromethorphan (DM) hydrobromide combined with quinidine sulfate (Q) as treatment of PBA is described and the ongoing debates concerning the terminology for dysfunction of emotional expression, as well as the ongoing searches for its brain substrates are surveyed.

Mechanism of action of dextromethorphan/quinidine: comparison with ketamine

  • S. Stahl
  • Psychology, Medicine
    CNS Spectrums
  • 2013
Attempts are made to find an agent with ketamine's properties that can be administered orally in repeated doses in order to sustain that action, and here the pharmacologic mechanism of action is compared and contrasted with that of ketamine.
...

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