Dextroamphetamine-induced arousal in human subjects as a model for mania

  title={Dextroamphetamine-induced arousal in human subjects as a model for mania},
  author={D Jacobs and Trevor Silverstone},
  journal={Psychological Medicine},
  pages={323 - 329}
Synopsis Because of the practical difficulties which arise in studying manic patients, a reproducible model for mania using human subjects would be a valuable adjunct to research in this condition. Dextroamphetamine, given as a single oral 20 mg dose, fulfils the criteria for such a model in that there are very close similarities between the changes which occur after dextroamphetamine and those which have been observed in mania in terms of subjective experience, physiological and endocrine… 

Valproate attenuates dextroamphetamine-induced subjective changes more than lithium

Guanfacine and secondary mania in children.

Lithium and valproate attenuate dextroamphetamine‐induced changes in brain activation

The effect of 14 days pretreatment with lithium and valproate on these dextroamphetamine‐induced changes in regional brain activity in healthy volunteers is assessed.

Cabergoline associated with first episode mania.

Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers

While dextro‐amphetamine administration definitely causes several changes which are seen in mania, there remain some physiological and metabolic differences between these two conditions.

Antidopaminergic effects of dietary tyrosine depletion in healthy subjects and patients with manic illness

Decreased tyrosine availability to the brain attenuates pathological increases in dopamine neurotransmission following methamphetamine administration and putatively in mania.

Behavioral and pharmacological assessment of a potential new mouse model for mania

Dextro‐amphetamine increases phosphoinositol cycle activity in volunteers: an MRS study

To help determine the effects of dextro‐amphetamine on the phosphoinositol cycle (PI‐cycle) in humans, 1H and 31P magnetic resonance spectroscopy (MRS) was utilized in 17 healthy volunteers. This was



Blockade of intravenous amphetamine euphoria in man

In subjects who abuse amphetamine, the euphoric effect of 200 mg. of D,L‐amphetamine intravenously was reduced or abolished by oral pretreatment with α‐methyl‐p‐tyrosine (α‐MT) 2.0 to 4.0 Gm. The

Levoamphetamine and dextroamphetamine: comparative efficacy in the hyperkinetic syndrome. Assessment by target symptoms.

In a nine-week double-blind crossover comparison of dextroamphetamine, levoamphetamine (Cydril), and placebo with 11 hyperkinetic children, effects were assessed by an established teacher rating

d-Amphetamine-induced heterogeneous changes in psychotic behavior in schizophrenia.

The authors suggest that sensitivity to dopamine stimulation in schizophrenia is state-dependent rather than trait-dependent and that the simple, undirectional hypothesis of schizophrenia needs to be reformulated.

Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man

This study suggests that it is unlikely that these central actions in man are a consequence of the release of norepinephrine in the brain, and suggests that these five agents share a common mode of central action.

Corticosteroid and growth hormone responses to methylamphetamine in depressive illness

  • S. Checkley
  • Psychology, Biology
    Psychological Medicine
  • 1979
Findings support the hypothesis that there is a functional deficiency of noradrenaline at some central α-adrenergic receptors.

Variable attenuation of amphetamine effects by lithium.

In an open study of 8 subjects, approximately half showed some attenuation of CNS stimulant effects of amphetamine after pretreatment with lithium. Two showed specific blockade of euphoria, with

Antimanic effect of clonidine.

This work hypothesized that the use of a stimulant of a-admenengic pnesynaptic receptors, which reduces the melease of nomepinephrine, might be effective in the treatment of manic states and explored cbonidine because its central effects have received some support.

Inhibition of dopamine-b-hydroxylase in manic patients. A clinical trial and fusaric acid.

Conventional antimanic therapies, initiated after the fusaric acid protocol, were associated with improvement in the expected time period in all patients and provides a test of the NE hypothesis of mania.