Dextro-naloxone counteracts amphetamine-induced hyperactivity.


The locomotor stimulating effect of d-amphetamine in mice was counteracted by the administration of l-naloxone [(-)-naloxone], a known opiate receptor antagonist. Mice injected with amphetamine reached a peak locomotor activity within 30 min. When treated simultaneously with amphetamine and l-naloxone, these subjects showed low motility. Furthermore, when mice were treated not with l-naloxone but with its mirror image, d-naloxone [(+)-naloxone], a compound that by itself does not antagonize opiates and does not affect spontaneous motility, they showed no amphetamine-induced hyperactivity. The finding that an enantiomer of naloxone, with no opiate antagonist activity, is able to block the excitatory action of amphetamine, suggests the existence of a hitherto unknown mechanism of counteracting some of the effects of stimulants and euphoriants like amphetamine and cocaine.


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@article{Chatterjie1998DextronaloxoneCA, title={Dextro-naloxone counteracts amphetamine-induced hyperactivity.}, author={Nithiananda Chatterjie and Jeri Altneu Sechzer and Kenneth W. Lieberman and George Alexander}, journal={Pharmacology, biochemistry, and behavior}, year={1998}, volume={59 2}, pages={271-4} }