Dextrans and Glycogens as Particulate Tracers for Studying Capillary Permeability

@article{Simionescu1971DextransAG,
  title={Dextrans and Glycogens as Particulate Tracers for Studying Capillary Permeability},
  author={Nicolae Simionescu and George Emil Palade},
  journal={The Journal of Cell Biology},
  year={1971},
  volume={50},
  pages={616 - 624}
}
Commercially available glycogens and dextrans can be used as biological particulate tracers in work on capillary permeability. These polysaccharides are well tolerated in intravenous injection and induce no vascular leakage when applied topically (cremaster test) in mice and in Wistar-Furth rats. The particles stain adequately with lead after aldehyde-OsO(4) fixation in phosphate buffer and provide a relatively wide set of probes ( approximately 45 A-300 A) for work on the large and small pore… CONTINUE READING
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