Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon

@inproceedings{Laroui2012DextranSS,
  title={Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon},
  author={Hamed Laroui and Sarah A. Ingersoll and Hong Liu and Mark T. Baker and Saravanan Ayyadurai and Moiz A. Charania and Famina Laroui and Yutao Yan and Shanthi V. Sitaraman and Didier Merlin},
  booktitle={PloS one},
  year={2012}
}
Inflammatory bowel diseases (IBDs), primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model. DSS induces in vivo but not in vitro intestinal inflammation. In addition, no DSS-associated molecule (free glucose, sodium sulfate solution, free dextran) induces in vitro or in vivo intestinal inflammation. We find that DSS but not dextran associated molecules… CONTINUE READING
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