Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice.

@article{Chen2019DextranConjugatedCS,
  title={Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice.},
  author={Changmai Chen and Zhong-yu Wang and Jinhao Zhang and Xinli Fan and Luzheng Xu and Xinjing Tang},
  journal={Bioconjugate chemistry},
  year={2019},
  volume={30 5},
  pages={
          1459-1465
        }
}
RNA interference (RNAi)-based gene therapy is a precision therapeutic approach for highly efficient sequence-specific gene silencing in vivo or in vitro. Caged RNAs featuring dextran conjugation of antisense and sense RNA strands using photolabile linker were rationally designed and self-assembled to form caged siRNA nanoparticles (Dex- p-siRNA) for photoregulation of target gene expression. The dextran-conjugated caged siRNA nanoparticles showed significant serum nuclease-resistance due to the… Expand
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