Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation

@article{Ruokonen2008DexmedetomidineVP,
  title={Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation},
  author={Esko Ruokonen and Ilkka Parviainen and Stephan M. Jakob and S{\'i}lvia Nunes and Maija Kaukonen and Stephen T. Shepherd and Toni Sarapohja and J. Raymond Bratty and Jukka Takala},
  journal={Intensive Care Medicine},
  year={2008},
  volume={35},
  pages={282-290}
}
To compare dexmedetomidine (DEX) with standard care (SC, either propofol or midazolam) for long-term sedation in terms of maintaining target sedation and length of intensive care unit (ICU) stay. A pilot, phase III, double-blind multicenter study in randomized medical and surgical patients (n = 85) within the first 72 h of ICU stay with an expected ICU stay of ≥48 h and sedation need for ≥24 h after randomization. Patients were assigned to either DEX (≤1.4 μg kg−1 h−1; n = 41) or SC (n = 44… CONTINUE READING
73 Citations
23 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 73 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Similar Papers

Loading similar papers…