Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit.

@article{Zheng2012DexmedetomidinePR,
  title={Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit.},
  author={Yaguo Zheng and SongQing Cui and Yue Liu and Jianguo Zhang and Wei Zhang and Jing Zhang and X. P. Gu and Zhengya Ma},
  journal={Brain research bulletin},
  year={2012},
  volume={87 4-5},
  pages={427-31}
}
Numerous studies have demonstrated that prolonged opioid exposure can enhance pain sensitivity that presents as opioid-induced hyperalgesia (OIH). Activation of spinal α2-adrenergic receptor may play an important role in the development of OIH. Dexmedetomidine is an α2-adrenergic agonist that has been shown to synergize with opioids. The aim of this study was to investigate the antihyperalgesia effects of dexmedetomidine on remifentanil-induced postinfusion hyperalgesia in a rat model of… CONTINUE READING

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