Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury

@article{Lempiinen2014DexmedetomidinePA,
  title={Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury},
  author={J. Lempi{\"a}inen and P. Finckenberg and E. Mervaala and M. Storvik and J. Kaivola and K. Lindstedt and J. Levijoki},
  journal={Pharmacology Research \& Perspectives},
  year={2014},
  volume={2}
}
Kidney ischemia‐reperfusion (I/R) injury is a common cause of acute kidney injury. We tested whether dexmedetomidine (Dex), an alpha2 adrenoceptor (α2‐AR) agonist, protects against kidney I/R injury. Sprague–Dawley rats were divided into four groups: (1) Sham‐operated group; (2) I/R group (40 min ischemia followed by 24 h reperfusion); (3) I/R group + Dex (1 μg/kg i.v. 60 min before the surgery), (4) I/R group + Dex (10 μg/kg). The effects of Dex postconditiong (Dex 1 or 10 μg/kg i.v. after… Expand
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