Dexmedetomidine in Children: Current Knowledge and Future Applications
@article{Mason2011DexmedetomidineIC, title={Dexmedetomidine in Children: Current Knowledge and Future Applications}, author={Keira P. Mason and Jerrold Lerman}, journal={Anesthesia \& Analgesia}, year={2011}, volume={113}, pages={1129–1142} }
More than 200 studies and reports have been published regarding the use of dexmedetomidine in infants and children. We reviewed the English literature to summarize the current state of knowledge of this drug in children for the practicing anesthesiologist. Dexmedetomidine is an effective sedative for infants and children that only minimally depresses the respiratory system while maintaining a patent airway. However, dexmedetomidine does depress the cardiovascular system. Specifically…
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References
SHOWING 1-10 OF 166 REFERENCES
The use of dexmedetomidine in critically ill children
- MedicinePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
- 2009
It is suggested that many, although not all, mechanically ventilated children may be able to reduce their need for other sedation medications with the use of dexmedetomidine, however, the potential side effects of Dexmedetamidine necessitates close hemodynamic monitoring with its use.
Prolonged dexmedetomidine infusions in critically ill infants and children.
- MedicineIndian pediatrics
- 2009
Prolonged DEX infusions were associated with a reduction in concomitant analgesia and sedation medications and was well tolerated with the exception of heart rate, which decreased during the initiation of therapy but may not represent a clinically significant reduction.
The Effects of Dexmedetomidine on Cardiac Electrophysiology in Children
- Medicine, BiologyAnesthesia and analgesia
- 2008
The use of DEX may not be desirable during electrophysiology study and may be associated with adverse effects in patients at risk for bradycardia or atrioventricular nodal block.
Use of dexmedetomidine in children after cardiac and thoracic surgery*
- MedicinePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
- 2006
The data suggest that dexmedetomidine is a well-tolerated and effective agent for both spontaneously breathing and mechanically ventilated patients following congenital cardiac and thoracic surgery.
Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: Preliminary study*
- MedicinePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
- 2007
Dexmedetomidine, administered as a continuous infusion, produces consistent, predictable concentrations in children and infants, and further evaluations of the safety, efficacy, and pharmacodynamics are warranted.
Prolonged use of dexmedetomidine in the paediatric cardiothoracic intensive care unit
- MedicineCardiology in the Young
- 2009
Abstract Background Dexmedetomidine is an α2-adrenergic agonist that causes sleep-like sedation and mild analgesia without narcosis or respiratory depression, and has relative cardiovascular…
Bradycardia During Dexmedetomidine and Therapeutic Hypothermia
- MedicineJournal of intensive care medicine
- 2008
2 pediatric patients with traumatic brain injury who had good long-term neurologic outcomes, but developed clinically significant bradycardia when therapeutic hypothermia was added to a sedation regimen that included dexmedetomidine and remifentanil are reported.
Dexmedetomidine sedation for pediatric post-Fontan procedure patients
- MedicinePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
- 2009
The results of this retrospective review of the role of DEX in the management of the post-Fontan surgical pediatric patient indicate some potential advantages.
A new dosing protocol reduces dexmedetomidine-associated hypotension in critically ill surgical patients.
- MedicineJournal of critical care
- 2009
Sedation Using Dexmedetomidine in Pediatric Burn Patients
- MedicineJournal of burn care & research : official publication of the American Burn Association
- 2006
A retrospective chart review of 65 pediatric burn patients admitted in the intensive care unit admitted between 2001 and 2004 who received DEX infusion because of failure to achieve adequate sedation with standard regimen of opioids and benzodiazepines found that DEX would improve sedation compared with standard sedation regimen.