Dexmedetomidine for Improved Quality of Emergence From General Anesthesia: A Dose-Finding Study.

@article{Aouad2017DexmedetomidineFI,
  title={Dexmedetomidine for Improved Quality of Emergence From General Anesthesia: A Dose-Finding Study.},
  author={Marie T. Aouad and Carine Zeeni and Rony Al Nawwar and Sahar M. Siddik-Sayyid and Hanane B Barakat and Sandra El{\'i}as and Vanda G Yazbeck Karam},
  journal={Anesthesia and analgesia},
  year={2017}
}
BACKGROUND Dexmedetomidine provides smooth and hemodynamically stable emergence at the expense of hypotension, delayed recovery, and sedation. We investigated the optimal dose of dexmedetomidine for prevention of cough, agitation, hypertension, tachycardia, and shivering, with minimal side effects. METHODS In this prospective, randomized, double-blind trial, 216 adult patients were randomly assigned to dexmedetomidine 1 µg/kg (D 1), 0.5 µg/kg (D 0.5), 0.25 µg/kg (D 0.25), or control (C… CONTINUE READING