Dexmedetomidine decreases cerebral blood flow velocity in humans.

  title={Dexmedetomidine decreases cerebral blood flow velocity in humans.},
  author={Mark H. Zornow and Mervyn M Maze and J B Dyck and Steven L. Shafer},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={13 2},
This study was designed to determine the effects of dexmedetomidine on CBF velocity as measured by transcranial Doppler sonography in human volunteers. Dexmedetomidine, a potent alpha-2 adrenergic agonist, was administered by computer-driven infusion pump to six male volunteers. Serial measurements of middle cerebral artery blood flow velocity at four steady-state plasma concentrations of dexmedetomidine were made with a 2-MHz transcranial Doppler transducer via the temporal window. The… CONTINUE READING


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