Dexfenfluramine increases pulmonary artery smooth muscle intracellular Ca2+, independent of membrane potential.

@article{Reeve1999DexfenfluramineIP,
  title={Dexfenfluramine increases pulmonary artery smooth muscle intracellular Ca2+, independent of membrane potential.},
  author={H. Reeve and S. Archer and M. Soper and E. Weir},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1999},
  volume={277 3},
  pages={L662-L666}
}
  • H. Reeve, S. Archer, +1 author E. Weir
  • Published 1999
  • Medicine, Chemistry
  • American journal of physiology. Lung cellular and molecular physiology
  • The anorexic agent dexfenfluramine causes the development of primary pulmonary hypertension in susceptible patients by an unknown mechanism that may include changes in K+-channel activity and intracellular Ca2+ concentration ([Ca2+]i). We investigated the dose-dependent effects of dexfenfluramine on [Ca2+]i, K+ current, and membrane potential in freshly dispersed rat pulmonary artery smooth muscle cells. Dexfenfluramine caused a dose-dependent (1-1,000 μM) increase in [Ca2+]i, even at… CONTINUE READING
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    • 52
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    • 170
    • PDF
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    • 92
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    • 119
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 15 REFERENCES
    Primary pulmonary hypertension.
    • 1,450
    • PDF