Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension

@inproceedings{Dempsie2013DexfenfluramineAT,
  title={Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension},
  author={Yvonne Dempsie and Neil Macritchie and Kevin H White and Ian Morecroft and Audrey F. Wright and Margaret Nilsen and Lynn Loughlin and Kirsty M. Mair and Margaret R. Maclean},
  booktitle={Cardiovascular research},
  year={2013}
}
AIMS Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH. Dfen mediates PAH via a serotonergic mechanism and we have shown serotonin to up-regulate expression of CYP1B1 in human pulmonary artery smooth muscle cells (PASMCs). Thus here we assess the role of… CONTINUE READING
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