Dexfenfluramine and serotonin neurotoxicity: further preclinical evidence that clinical caution is indicated.

@article{McCann1994DexfenfluramineAS,
  title={Dexfenfluramine and serotonin neurotoxicity: further preclinical evidence that clinical caution is indicated.},
  author={Una D. McCann and George Hatzidimitriou and Alison Ridenour and Catherine G Fischer and Jie Yuan and J L Katz and George A. Ricaurte},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={269 2},
  pages={792-8}
}
Dexfenfluramine, a drug used as an appetite suppressant in Europe, is currently under evaluation for approval in the United States. Studies in animals indicate that dexfenfluramine damages brain serotonin neurons, but have been challenged by some because of questions regarding their relevance to humans. The present studies were designed to address the three most salient questions regarding the applicability of preclinical dexfenfluramine neurotoxicity data to humans. Specifically, the present… CONTINUE READING

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