Dexamethasone upregulates 11beta-hydroxysteroid dehydrogenase type 2 in BEAS-2B cells.

  title={Dexamethasone upregulates 11beta-hydroxysteroid dehydrogenase type 2 in BEAS-2B cells.},
  author={Satoshi Suzuki and Kaori Koyama and Andrew D. Darnel and Hironori Ishibashi and Seiichi Kobayashi and Hiroshi Kubo and Takashi Suzuki and Hironobu Sasano and Zygmund S Krozowski},
  journal={American journal of respiratory and critical care medicine},
  volume={167 9},
The actions of natural and synthetic glucocorticoids are in part determined by 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2). We examined whether carbenoxolone, a potent inhibitor of 11beta-HSD, would potentiate the inhibitory action of dexamethasone on interleukin-8 release from BEAS-2B cells, and whether prolonged treatment with dexamethasone at therapeutic doses would upregulate 11beta-HSD2 in the cells. We found that carbenoxolone increased the potency of dexamethasone almost 10… CONTINUE READING
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