Dexamethasone up-regulates skeletal muscle maximal Na+,K+ pump activity by muscle group specific mechanisms in humans.

@article{Nordsborg2005DexamethasoneUS,
  title={Dexamethasone up-regulates skeletal muscle maximal Na+,K+ pump activity by muscle group specific mechanisms in humans.},
  author={Nikolai B Nordsborg and Craig Goodmann and Michael J. McKenna and Jens Bangsbo},
  journal={The Journal of physiology},
  year={2005},
  volume={567 Pt 2},
  pages={583-9}
}
Dexamethasone, a widely clinically used glucocorticoid, increases human skeletal muscle Na+,K+ pump content, but the effects on maximal Na+,K+ pump activity and subunit specific mRNA are unknown. Ten healthy male subjects ingested dexamethasone for 5 days and the effects on Na+,K+ pump content, maximal activity and subunit specific mRNA level (alpha1, alpha2, beta1, beta2, beta3) in deltoid and vastus lateralis muscle were investigated. Before treatment, maximal Na+,K+ pump activity, as well as… CONTINUE READING

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