Dexamethasone treatment increases mitochondrial RNA synthesis in a rat hepatoma cell line.

@article{Itallie1992DexamethasoneTI,
  title={Dexamethasone treatment increases mitochondrial RNA synthesis in a rat hepatoma cell line.},
  author={Christina M Van Itallie},
  journal={Endocrinology},
  year={1992},
  volume={130 2},
  pages={567-76}
}
Glucocorticoid hormones act in the nucleus of the cell to alter expression of specific genes and change cell metabolism. In liver, these hormones have been reported to increase mitochondrial respiratory activity, which is regulated by both nuclear and mitochondrial gene products. We examined the effects of the synthetic glucocorticoid, dexamethasone, on the expression of mitochondrially encoded genes in a rat hepatoma cell line, H-4-II-E cells. Dexamethasone treatment of these cells increased… CONTINUE READING

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