Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function.

@article{Gandhi2010DexamethasoneSW,
  title={Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function.},
  author={Anita K. Gandhi and J Kang and Lori Capone and Anastasia Parton and Lina Wu and Li Hua Zhang and Derek Mendy and Antonia Lopez-Girona and Tim Q. Tran and Lisa M. Sapinoso and Weiyi Fang and S G Xu and Garret Hampton and Jake Blake Bartlett and Peter Schafer},
  journal={Current cancer drug targets},
  year={2010},
  volume={10 2},
  pages={155-67}
}
To determine the effect of dexamethasone on the antimyeloma effects of lenalidomide, we tested in vitro proliferation, tumor suppressor gene expression, caspase activity, cell cycling, and apoptosis levels in a series of multiple myeloma (MM) and plasma cell leukemia cell lines treated with lenalidomide and dexamethasone, alone or in combination. The effect of dexamethasone on the immunomodulatory activities of lenalidomide such as T cell and natural killer (NK) cell activation was measured via… CONTINUE READING
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