Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles.

@article{Schfer2005DexamethasoneSE,
  title={Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles.},
  author={S. C. Sch{\"a}fer and Thomas Wallerath and Ellen Ildicho Closs and Ch. Schmidt and Petra M. Schwarz and Ulrich Foerstermann and H-A Lehr},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 1},
  pages={H436-44}
}
Long-term treatment with glucocorticoids is associated with mild to moderate hypertension. We reported previously that downregulation of endothelial NO synthase (eNOS) expression and activity is likely to contribute to this increase in blood pressure. In the present study, we tested the effects of dexamethasone on the vasodilation of microvascular arterioles using implanted dorsal skin-fold chambers in anesthetized C57BL/6J mice. Experiments were performed on control mice or on mice treated… CONTINUE READING