Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium.

@article{Harkness2000DexamethasoneRO,
  title={Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium.},
  author={Kristen A. Harkness and P Adamson and Jon D Sussman and G. A. B. Davies-Jones and John Greenwood and M. Nicola Woodroofe},
  journal={Brain : a journal of neurology},
  year={2000},
  volume={123 ( Pt 4)},
  pages={
          698-709
        }
}
Matrix metalloproteinases (MMPs) have been implicated in the early breakdown of the blood-brain barrier in neuroinflammatory disease. Although expression of these enzymes by resident glial cells and recruited immune cells has been described, altered expression of MMPs by the CNS vascular endothelial cells may also contribute to barrier disruption. In the present study, the in vitro expression of MMP-2 and -9 as well as tissue inhibitor of metalloproteinase (TIMP)-2 by rat CNS microvascular… CONTINUE READING

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