Dexamethasone prevents transport inhibition by hypoxia in rat lung and alveolar epithelial cells by stimulating activity and expression of Na+-K+-ATPase and epithelial Na+ channels.

@article{Gney2007DexamethasonePT,
  title={Dexamethasone prevents transport inhibition by hypoxia in rat lung and alveolar epithelial cells by stimulating activity and expression of Na+-K+-ATPase and epithelial Na+ channels.},
  author={Sevin G{\"u}ney and Akelei Schuler and Alexandra Ott and Sabine H{\"o}schele and Stefanie Z{\"u}gel and Emel Baloğlu and Peter D B{\"a}rtsch and Heimo Mairb{\"a}url},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 5},
  pages={L1332-8}
}
Hypoxia inhibits Na and lung fluid reabsorption, which contributes to the formation of pulmonary edema. We tested whether dexamethasone prevents hypoxia-induced inhibition of reabsorption by stimulation of alveolar Na transport. Fluid reabsorption, transport activity, and expression of Na transporters were measured in hypoxia-exposed rats and in primary alveolar type II (ATII) cells. Rats were treated with dexamethasone (DEX; 2 mg/kg) on 3 consecutive days and exposed to 10% O(2) on the 2nd and… CONTINUE READING

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