Dexamethasone prevents long-lasting learning impairment following neonatal hypoxic–ischemic brain insult in rats

@article{Ikeda2002DexamethasonePL,
  title={Dexamethasone prevents long-lasting learning impairment following neonatal hypoxic–ischemic brain insult in rats},
  author={Tomoaki Ikeda and Kenichi Mishima and Tetsuya Yoshikawa and Katsunori Iwasaki and Tsuyomu Ikenoue},
  journal={Behavioural Brain Research},
  year={2002},
  volume={136},
  pages={161-170}
}
We examined for 18 weeks the effect of dexamethasone treatment on learning and memory impairment produced by hypoxic-ischemic stress at postnatal day 7 in rat in addition to brain histological study. Dexamethasone of 0.5 mg/kg was injected i.p. 4 h before hypoxic-ischemic stress, in which the left carotid artery was ligated followed by 2 h hypoxia (8% oxygen). Dexamethasone treatment improved behavior in each learning task: in choice reaction time tasks relating to the attention process, in 8… CONTINUE READING

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