Dexamethasone prevents alteration of tight junction-associated proteins and barrier function in porcine choroid plexus epithelial cells after infection with <ce:italic>Streptococcus suis</ce:italic> in vitro

@article{Tenenbaum2008DexamethasonePA,
  title={Dexamethasone prevents alteration of tight junction-associated proteins and barrier function in porcine choroid plexus epithelial cells after infection with <ce:italic>Streptococcus suis</ce:italic> in vitro},
  author={Tobias Tenenbaum and David Matalon and R{\"u}diger A Adam and Annette Seibt and Corinna Wewer and Christian Schwerk and Hans-Joachim Galla and Horst Schroten},
  journal={Brain Research},
  year={2008},
  volume={1229},
  pages={1-17}
}
Apart from antibiotic treatment in bacterial meningitis supportive therapy including dexamethasone is widely used. In investigations on the pathogenesis of bacterial meningitis we previously demonstrated that Streptococcus suis (S. suis), a relevant cause of bacterial meningitis in pigs and humans, affects porcine choroid plexus epithelial cell (PCPEC) barrier function. The choroid plexus epithelium constitutes the structural basis of the blood-CSF barrier. Now, we investigated the role of… CONTINUE READING
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