Dexamethasone pretreatment provides antiinflammatory and myocardial protection in neonatal arterial switch operation.

@article{Heying2012DexamethasonePP,
  title={Dexamethasone pretreatment provides antiinflammatory and myocardial protection in neonatal arterial switch operation.},
  author={Ruth Heying and Edith Wehage and Katharina Schumacher and Peter Tassani and Felix de Haas and Rudiger Lange and John Hess and M Seghaye},
  journal={The Annals of thoracic surgery},
  year={2012},
  volume={93 3},
  pages={869-76}
}
BACKGROUND This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the systemic inflammatory reaction upon cardiac operation, and provide organ protection in neonates. METHODS Twenty neonates (age, 8 to 21 days) with transposition of the great arteries scheduled for arterial switch operation were included. Nine received dexamethasone (1 mg/kg body weight) 4 hours before… CONTINUE READING
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