Dexamethasone pharmacokinetics in Guinea pig inner ear perilymph.

  title={Dexamethasone pharmacokinetics in Guinea pig inner ear perilymph.},
  author={Hong-Jian Liu and Ming-min Dong and Fang-lu Chi},
  journal={ORL; journal for oto-rhino-laryngology and its related specialties},
  volume={68 2},
AIM To study the dexamethasone pharmacokinetics in the inner ear perilymph of guinea pigs using high-pressure liquid chromatography. METHODS Sixty-five guinea pigs were divided into three groups. In the first group, the drug application protocol used an intra-abdominal dose of 0.5% dexamethasone 4 mg x kg(-1). In the second group, an intratympanic application dose of 0.5% dexamethasone 150 microl was used. The third group was the control group. The concentrations of dexamethasone in inner ear… CONTINUE READING

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Dexamethasone levels and base-to-apex concentration gradients in the scala tympani perilymph after intracochlear delivery in the guinea pig.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology • 2012

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