Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19

  title={Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19},
  author={Sarthak Sinha and Nicole L Rosin and Rohit Arora and Elodie Labit and Arzina Jaffer and Leslie Cao and Raquel Farias and Angela P Nguyen and Luiz G. N. de Almeida and Antoine Dufour and Amy Bromley and Braedon McDonald and Mark R. Gillrie and Marvin J. Fritzler and Bryan G. Yipp and Jeff Biernaskie},
  journal={Nature Medicine},
  pages={201 - 211}
Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens, is unclear. Moreover, mechanisms underlying the beneficial effects of dexamethasone during severe COVID-19 remain elusive. Using single-cell RNA sequencing and plasma proteomics, we discovered that, compared to bacterial ARDS, COVID-19 was… 

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