Dexamethasone inhibits the differentiation of rat tendon stem cells into tenocytes by targeting the scleraxis gene.

@article{Chen2015DexamethasoneIT,
  title={Dexamethasone inhibits the differentiation of rat tendon stem cells into tenocytes by targeting the scleraxis gene.},
  author={Wan Yi Chen and Hong Tang and Mei Zhou and Chao Hu and Jiqiang Zhang and Kanglai Tang},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2015},
  volume={152},
  pages={16-24}
}
Glucocorticoid-induced tendon rupture is very common in clinical practice, and the overall outcome of surgical suture repair is rather poor. The mechanism remains unclear, and effective treatments are still lacking. In the present study, we investigated the effect of dexamethasone on the differentiation of rat tendon stem cells (TSCs) to tenocytes and the underlying molecular mechanisms and found that dexamethasone inhibits the differentiation of TSCs to tenocytes by analyzing the development… CONTINUE READING