Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction.

@article{Petrella2006DexamethasoneIT,
  title={Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction.},
  author={Antonello Petrella and Simona Francesca Ercolino and Michela Festa and Antonio Gentilella and Alessandra Tosco and Suzanne D. Conzen and Luca Parente},
  journal={European journal of cancer},
  year={2006},
  volume={42 18},
  pages={3287-93}
}
We have investigated the effect of dexamethasone (DEX) on the apoptosis induced by TRAIL (tumour necrosis factor-related apoptosis inducing ligand) in follicular undifferentiated thyroid (FRO) cancer cells. Apoptosis was measured by percent hypodiploid nuclei, caspase-3 and -8 activation, and mitochondrial membrane depolarisation. DEX nearly abolished TRAIL-induced apoptosis. The DEX protective effect was reverted by the steroid receptor antagonist RU486 suggesting that the DEX action is… CONTINUE READING