Dexamethasone inhibits TNF-alpha synthesis more effectively in Alzheimer's disease patients than in healthy individuals.

@article{Dziedzic2003DexamethasoneIT,
  title={Dexamethasone inhibits TNF-alpha synthesis more effectively in Alzheimer's disease patients than in healthy individuals.},
  author={Tomasz Dziedzic and Iwona Wybrańska and Aldona Dembińska-Ki{\'e}c and Aleksandra Klimkowicz and Agnieszka Julia Slowik and Joanna Pankiewicz and Anna Zdzienicka and Andrzej Szczudlik},
  journal={Dementia and geriatric cognitive disorders},
  year={2003},
  volume={16 4},
  pages={283-6}
}
Inflammatory mechanisms are involved in the pathogenesis of Alzheimer's disease (AD). It is postulated that cytokine synthesis is altered in AD patients compared with nondemented subjects. Glucocorticoids play an important role in cytokine synthesis. We assessed the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10) and interleukin-12 (IL-12) and its regulation by dexamethasone in AD patients in vitro. Cytokine levels were measured using the ELISA method in unstimulated… CONTINUE READING

Similar Papers

Loading similar papers…