Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects.

@article{Miell1996DexamethasoneIA,
  title={Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects.},
  author={John P Miell and Piera Englaro and Werner Friedrich Blum},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={1996},
  volume={28 12},
  pages={704-7}
}
Leptin, the protein product of the ob gene, is thought to have a role in signalling satiety through hypothalamic pathways. Glucocorticoids are potent stimulators of both ob gene expression and circulating leptin levels in the rat, yet are powerful appetite stimulants in humans. We have investigated circulating leptin responses to intermediate term and acute administration of dexamethasone. Dexamethasone 2 mg twice daily resulted in a rapid and sustained rise in 08.00 h leptin levels from basal… CONTINUE READING

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