Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits. Possible mechanisms.

  title={Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits. Possible mechanisms.},
  author={Kazuhisa Asai and Chiaki Funaki and Toshio Hayashi and Koutaro Yamada and Michitaka Naito and Masafumi Kuzuya and Futoshi Yoshida and Noboru Yoshimine and Fumio Kuzuya},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  volume={13 6},
We investigated the mechanisms by which corticosteroids affect atherosclerosis. Male New Zealand White rabbits were injected with 0.125 mg dexamethasone (n = 10) or vehicle (control group, n = 10). Both groups were fed a 1% cholesterol diet for 8 weeks. Although the dexamethasone-treated animals exhibited a greater degree of hyperlipidemia, they exhibited significantly less atherosclerotic plaque of the aortic surface than control animals (7.8% versus 47.2%). Immunofluorescence study of the… CONTINUE READING
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