Dexamethasone-induced killing of neoplastic cells of lymphoid derivation: lack of early calcium involvement.

Abstract

The role of calcium influx in dexamethasone-induced fragmentation of DNA was studied in the glucocorticoid-sensitive human lymphoid line of T cell derivation (CEM-C7). Reduction of calcium content in the medium or the use of EGTA increased DNA fragmentation and appeared to slightly enhance the effect of dexamethasone. Incubation of isolated nuclei in the… (More)

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@article{Bansal1990DexamethasoneinducedKO, title={Dexamethasone-induced killing of neoplastic cells of lymphoid derivation: lack of early calcium involvement.}, author={Nikhil Bansal and Andrea Houle and George Melnykovych}, journal={Journal of cellular physiology}, year={1990}, volume={143 1}, pages={105-9} }