Dexamethasone-induced insulin resistance and pancreatic adaptive response in aging rats are not modified by oral vanadyl sulfate treatment.

@article{Barbera2001DexamethasoneinducedIR,
  title={Dexamethasone-induced insulin resistance and pancreatic adaptive response in aging rats are not modified by oral vanadyl sulfate treatment.},
  author={Michele Barbera and Vanna Fierabracci and Michela Novelli and Marek Bombara and Pellegrino Masiello and Ettore Bergamini and Vincenzo De Tata},
  journal={European journal of endocrinology},
  year={2001},
  volume={145 6},
  pages={799-806}
}
OBJECTIVE To explore the adaptive response of the endocrine pancreas in vivo and in vitro and the possible beneficial effect of the insulino-mimetic agent vanadyl sulfate (VOSO(4)), using glucocorticoid treatment to increase insulin resistance, in aging rats. DESIGN AND METHODS Dexamethasone (Dex) (0.13 mg/kg b.w.) was administered daily for 13 days to 3- and 18-month old Sprague-Dawley rats and oral VOSO(4) was given from the 5th day. Plasma glucose, insulin and free fatty acids (FFA… CONTINUE READING
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