Dexamethasone-induced immunosuppression: a rabbit model.

  title={Dexamethasone-induced immunosuppression: a rabbit model.},
  author={Edita Jeklov{\'a} and Lenka Lev{\'a} and Zoran Jaglic and Martin Faldyna},
  journal={Veterinary immunology and immunopathology},
  volume={122 3-4},
Rabbits are often used as animal models for experimental purposes; in many cases steroid-induced immunosuppression is necessary. The aim of this study was to characterise a model of immunosuppression in rabbits, based on changes in the lymphocyte subset distribution, changes in proliferative capacity of lymphocytes and activity of neutrophils 1, 3 and 7 days after the administration of 2mg/kg dexamethasone phosphate (DXP) three times at 6-h intervals. In peripheral blood, neutrophilia and… CONTINUE READING