Dexamethasone induced cardiac hypertrophy in newborn rats is accompanied by changes in myosin heavy chain phenotype and gene transcription

@article{Muangmingsuk2000DexamethasoneIC,
  title={Dexamethasone induced cardiac hypertrophy in newborn rats is accompanied by changes in myosin heavy chain phenotype and gene transcription},
  author={Sunthorn Muangmingsuk and Paul A Ingram and M. V. N. V. Prasad Gupta and Ren{\'e} A. Arcilla},
  journal={Molecular and Cellular Biochemistry},
  year={2000},
  volume={209},
  pages={165-174}
}
Cardiac hypertrophy has been observed in newborn infants treated with dexamethasone (DEX). This study was undertaken to examine whether DEX-induced hypertrophy in newborn rats is associated with redistribution of cardiac myosin heavy chain (MHC) isoforms and if so, the effects involve transcriptional regulation. Newborn rats were injected with either DEX (1 mg/kg/day; s.c.) or equivalent volume normal saline for 1, 3, 5, 7 or 9 days. Hypertrophy was quantified by heart dry/wet wt ratios, heart… CONTINUE READING
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Cardiomyocytes and nonmuscle cells in cardiac hypertrophy: A molecular perspective

  • M Gupta, MP Gupta, RA Arcilla, R Zak
  • Prog Ped Cardiol
  • 1999
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DNA binding is induced by binding of the glucocorticoid receptor DNA binding domain and progestrone receptors to their response element

  • LN Petz, AM Nardulli, KB Horwitz, LP Freedman, DJ Shapiro
  • J Ster Biochem Mol Biol
  • 1997

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