Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance.

  title={Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance.},
  author={Rodrigo A. Troncoso and Felipe Paredes and Valentina Parra and Dami{\'a}n Gatica and C{\'e}sar V{\'a}squez-Trincado and Clara Quiroga and Roberto Bravo-Sagua and Camila Lopez-Crisosto and Andrea E Rodr{\'i}guez and Alejandra P Oyarz{\'u}n and Guido Kroemer and Sergio Lavandero},
  journal={Cell cycle},
  volume={13 14},
Glucocorticoids, such as dexamethasone, enhance protein breakdown via ubiquitin-proteasome system. However, the role of autophagy in organelle and protein turnover in the glucocorticoid-dependent atrophy program remains unknown. Here, we show that dexamethasone stimulates an early activation of autophagy in L6 myotubes depending on protein kinase, AMPK, and glucocorticoid receptor activity. Dexamethasone increases expression of several autophagy genes, including ATG5, LC3, BECN1, and SQSTM1 and… CONTINUE READING
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